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Overcoming the challenges of conducting translational research in cell therapy

Sowmya Viswanathan, Armand Keating

Frontiers of Medicine 2011, Volume 5, Issue 4,   Pages 333-335 doi: 10.1007/s11684-011-0166-2

Abstract: medical needs but despite its considerable impetus, faces numerous challenges including support for translationalresearch in this area.Here, we examine the challenges confronting cell therapy research including the limited funding availablefor translational research partly due to the uncompetitive nature of required validation studies in

Keywords： stem cells     clinical trials     funding     animal models     standardization     common definitions    

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Translational research on novel drug-eluting stents in percutaneous coronary intervention

Yaling Han, Kai Xu, Chenghui Yan

Frontiers of Medicine 2011, Volume 5, Issue 4,   Pages 395-400 doi: 10.1007/s11684-011-0167-1

Abstract: Translational research plays a very important role in experiments which determine the safety and efficacyThe present review focuses on translational research of novel DES, including drug discovery, creationof preclinical research models, planning and conducting of first-in-man studies, and developing next-generation

Keywords： translational research     drug-eluting stents     percutaneous coronary intervention    

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Error analysis and optimization of a 3-degree of freedom translational Parallel Kinematic Machine

S. SHANKAR GANESH,A. B. KOTESWARA RAO

Frontiers of Mechanical Engineering 2014, Volume 9, Issue 2,   Pages 120-129 doi: 10.1007/s11465-014-0300-3

Abstract:

In this paper, error modeling and analysis of a typical 3-degree of freedom translational ParallelThis mechanism provides translational motion along the Cartesian X-, Y- and 

Keywords： translational Parallel Kinematic Machine     error modeling     global error transformation index    

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Numerical analysis of hydrodynamic process of circular-translational-moving polishing (CTMP)

ZHAI Wenjie, LIU Changxiong, LIANG Yingchun

Frontiers of Mechanical Engineering 2008, Volume 3, Issue 4,   Pages 441-448 doi: 10.1007/s11465-008-0074-6

Abstract: a wafer along a circular path without rotation, we developed a polishing technique called circular-translational-moving

Keywords： numerical analysis     practical CTMP     circular-translational-moving polishing     CTMP     different    

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Bone metastasis of hepatocellular carcinoma: facts and hopes from clinical and translational perspectives

Frontiers of Medicine 2022, Volume 16, Issue 4,   Pages 551-573 doi: 10.1007/s11684-022-0928-z

Abstract: We also present the advances in the pathological and molecular mechanisms of HCC BM to shed light on translational

Keywords： HCC     bone     osteotropism     clinical     basic researches     advances    

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Stiffness of a 3-degree of freedom translational parallel kinematic machine

S. SHANKAR GANESH,A.B. KOTESWARA RAO

Frontiers of Mechanical Engineering 2014, Volume 9, Issue 3,   Pages 233-241 doi: 10.1007/s11465-014-0312-z

Abstract:

In this paper, a typical 3-degree of freedom (3-DOF) translational parallel kinematic machineUsing the stiffness modeling the variations of minimum and maximum translational stiffness in the workspace

Keywords： 3-DOF translational PKM     inverse kinematics     stiffness modeling     translational stiffness    

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Conceptual design of compliant translational joints for high-precision applications

Guangbo HAO,Haiyang LI,Xiuyun HE,Xianwen KONG

Frontiers of Mechanical Engineering 2014, Volume 9, Issue 4,   Pages 331-343 doi: 10.1007/s11465-014-0321-y

Abstract:

Compliant translational joints (CTJs) have been extensively used in precision engineering and microelectromechanical

Keywords： compliant mechanisms     translational joints     conceptual design     parallelogram     straight-line motion     combination    

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Dendritic cell vaccines in cancer immunotherapy: from biology to translational medicine

Hongmei Xu, Xuetao Cao

Frontiers of Medicine 2011, Volume 5, Issue 4,   Pages 323-332 doi: 10.1007/s11684-011-0172-4

Abstract:
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Design and analysis of partially decoupled translational parallel mechanisms with single-loop structures

Frontiers of Mechanical Engineering 2022, Volume 17, Issue 3, doi: 10.1007/s11465-022-0695-1

Abstract: This study presents a family of novel translational parallel mechanisms (TPMs) with single-loop topologicalThe workspace of the 3-CRR (C denotes the cylindrical joint and R denotes the revolute joint) translational

Keywords： translational parallel mechanism     single loop     multiple driving system     workspace analysis     singularity    

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Acupuncture-related techniques for the treatment of opiate addiction: a case of translational medicine

Jisheng Han, Cailian Cui, Liuzhen Wu

Frontiers of Medicine 2011, Volume 5, Issue 2,   Pages 141-150 doi: 10.1007/s11684-011-0136-8

Abstract: It has taken decades of research to optimize the parameters of electrical acupoint stimulation for detoxificationFollowing this, basic research on animals made it possible to understand the mechanisms of action anduse of acupuncture-related technique for the treatment of opiate addiction from the perspective of translational

Keywords： morphine     dependence     withdrawal     addiction     dynorphins     acupuncture     electroacupuncture     transcutaneous electrical acupoint stimulation (TEAS)     enkephalins     endorphins    

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improves insulin resistance in overweight/obese subjects with non-alcoholic fatty liver disease: a translational

Frontiers of Medicine 2022, Volume 16, Issue 5,   Pages 745-759 doi: 10.1007/s11684-021-0880-3

Abstract: This translational approach aimed to explore the effect and underlying mechanism of LGZG in clinical

Keywords： insulin resistance     non-alcoholic fatty liver disease     Chinese herbal medicine     randomized controlled trial     DNA N6-methyladenine modification    

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From Farming to Engineering: The Microbiota and Allergic Diseases

Dominique Angèle Vuitton, Jean-Charles Dalphin

Engineering 2017, Volume 3, Issue 1,   Pages 98-109 doi: 10.1016/J.ENG.2017.01.019

Abstract: However, the development of a new generation of probiotics based on very productive research on the farming

Keywords： Allergy     Farming     Microbial biodiversity     Immune regulation     Microbiota     Translational research    

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Translational medicine promising personalized therapy in oncology

Yi-Xin ZENG, Xiao-Shi ZHANG, Qiang LIU,

Frontiers of Medicine 2010, Volume 4, Issue 4,   Pages 351-355 doi: 10.1007/s11684-010-0320-2

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Decitabine induces -mediated immune responses in p53-mutated triple-negative breast cancer: a clinical and translational

Frontiers of Medicine doi: 10.1007/s11684-023-1016-8

Abstract: p53 is mutated in half of cancer cases. However, no p53-targeting drugs have been approved. Here, we reposition decitabine for triple-negative breast cancer (TNBC), a subtype with frequent p53 mutations and extremely poor prognosis. In a retrospective study on tissue microarrays with 132 TNBC cases, DNMT1 overexpression was associated with p53 mutations (P = 0.037) and poor overall survival (OS) (P = 0.010). In a prospective DEciTabinE and Carboplatin in TNBC (DETECT) trial (NCT03295552), decitabine with carboplatin produced an objective response rate (ORR) of 42% in 12 patients with stage IV TNBC. Among the 9 trialed patients with available TP53 sequencing results, the 6 patients with p53 mutations had higher ORR (3/6 vs. 0/3) and better OS (16.0 vs. 4.0 months) than the patients with wild-type p53. In a mechanistic study, isogenic TNBC cell lines harboring DETECT-derived p53 mutations exhibited higher DNMT1 expression and decitabine sensitivity than the cell line with wild-type p53. In the DETECT trial, decitabine induced strong immune responses featuring the striking upregulation of the innate immune player IRF7 in the p53-mutated TNBC cell line (upregulation by 16-fold) and the most responsive patient with TNBC. Our integrative studies reveal the potential of repurposing decitabine for the treatment of p53-mutated TNBC and suggest IRF7 as a potential biomarker for decitabine-based treatments.

Keywords： p53 mutation     triple-negative breast cancer     decitabine     DNMT1     IRF7     innate immune response    

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Translational initiatives in thrombolytic therapy

Melvin E. Klegerman

Frontiers of Medicine 2017, Volume 11, Issue 1,   Pages 1-19 doi: 10.1007/s11684-017-0497-8

Abstract:

Once thrombi have formed as part of the pathology defining myocardial infarction, ischemic stroke, peripheral arterial disease, deep venous thrombosis or other embolic disorders, the only clinically meaningful thrombolytic agents available for reversing the thrombogenic process are various plasminogen activators. These agents are enzymes that reverse fibrin polymerization underlying the coagulation process by converting endogenous plasminogen to plasmin, which cleaves the fibrin network to form increasingly smaller protein fragments, a process known as fibrinolysis. For the most part, the major clinically used thrombolytics, tissue plasminogen activator, urokinase and streptokinase, as well as the experimentally investigated agent staphylokinase, are the products of recombinant DNA technology, which permits molecular optimization of clinical efficacy. In all cases of molecular optimization and targeting, however, the primary challenge of thrombolytic therapy remains hemorrhagic side effects, which are especially devastating when they occur intracerebrally. Currently, the best strategy to ameliorate this adverse effect is nanoparticulate encapsulation or complexation, and many strategies of this sort are being actively pursued. This review summarizes the variety of targeted and untargeted thrombolytic formulations that have been investigated in preclinical studies.

Keywords： thrombolytics     nanomedicine     plasminogen activators    

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Title Author Date Type Operation

Overcoming the challenges of conducting translational research in cell therapy

Sowmya Viswanathan, Armand Keating

Journal Article

Translational research on novel drug-eluting stents in percutaneous coronary intervention

Yaling Han, Kai Xu, Chenghui Yan

Journal Article

Error analysis and optimization of a 3-degree of freedom translational Parallel Kinematic Machine

S. SHANKAR GANESH,A. B. KOTESWARA RAO

Journal Article

Numerical analysis of hydrodynamic process of circular-translational-moving polishing (CTMP)

ZHAI Wenjie, LIU Changxiong, LIANG Yingchun

Journal Article

Bone metastasis of hepatocellular carcinoma: facts and hopes from clinical and translational perspectives

Journal Article

Stiffness of a 3-degree of freedom translational parallel kinematic machine

S. SHANKAR GANESH,A.B. KOTESWARA RAO

Journal Article

Conceptual design of compliant translational joints for high-precision applications

Guangbo HAO,Haiyang LI,Xiuyun HE,Xianwen KONG

Journal Article

Dendritic cell vaccines in cancer immunotherapy: from biology to translational medicine

Hongmei Xu, Xuetao Cao

Journal Article

Design and analysis of partially decoupled translational parallel mechanisms with single-loop structures

Journal Article

Acupuncture-related techniques for the treatment of opiate addiction: a case of translational medicine

Jisheng Han, Cailian Cui, Liuzhen Wu

Journal Article

improves insulin resistance in overweight/obese subjects with non-alcoholic fatty liver disease: a translational

Journal Article

From Farming to Engineering: The Microbiota and Allergic Diseases

Dominique Angèle Vuitton, Jean-Charles Dalphin

Journal Article

Translational medicine promising personalized therapy in oncology

Yi-Xin ZENG, Xiao-Shi ZHANG, Qiang LIU,

Journal Article

Decitabine induces -mediated immune responses in p53-mutated triple-negative breast cancer: a clinical and translational

Journal Article

Translational initiatives in thrombolytic therapy

Melvin E. Klegerman

Journal Article